Dr.PainCLE said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
greg_boulder said:Agreed on adaptation, with a caveat: adaptation applies to gastric emptying and not to everything.
That reframing is the part I needed. Printing the relevant bit and taking it with me.
Dr.PainCLE said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.
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Browse GL BiochemOne concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.