TrialNerd_Beth said:Holding genuinely reduces total burden rather than redistributing it, because the gastric-emptying component adapts.
I dislike how confidently this board tells people to push through. Incidence figures around 20 to 25% at the higher doses are class-typical, but the trials also had a discontinuation column, and "manageable with protocols" is not the same as manageable for everyone.
Ask again with the specifics and you will get a better answer than this one.
One concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.
Dr.NutriCornell said:I dislike how confidently this board tells people to push through.
Coming at Dr.NutriCornell’s question from a different direction. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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Browse GL BiochemFollowing on from greg_boulder — and this may be the naive question:
What distinguishes the nausea you can titrate through from the nausea that means stop?
Closing the loop on my own question.
Update. It was not the dose, it was that I had stopped drinking anything because drinking made me feel full. Fixing that fixed most of it.