My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
What I am trying to establish is how much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical.
Not looking for reassurance. Looking for the part I have got wrong.
KarenAZ_mom said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 10 months of treatment.
The 5 criteria (and my journey):
- Waist circumference: 49" → 35" ✅ Resolved
- Triglycerides: 221 → 106 ✅ Resolved
- HDL: 33 → 53 ✅ Resolved
- Blood pressure: 141/91 → 119/73 ✅ Resolved
- Fasting glucose: 116 → 85 ✅ Resolved
Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.
mike_nyc said:Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 10 months of treatment.
mike_nyc said:...we're creating a generation dependent on cardiovascular risk...
I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?
Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.
If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.
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View ResultsKarenAZ_mom said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.
Clinical perspective, offered as context rather than as advice.
6 month update on cardiovascular risk: down 60 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.