Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
I would rather be corrected than agreed with, if it comes to it.
TirzTom said:Keep the original post as written when you update it, and add the correction underneath.
Thank you for spelling out the reasoning rather than just the conclusion.
Clinical perspective, offered as context rather than as advice. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
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Browse GL BiochemJenPlateau said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Same experience, arrived at from the opposite direction. The detail I would add is minor and it is already implied above.