KevinCompounds said:The RDA is the wrong reference and it is worth understanding why.
I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.
The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
Dr.ReproEndo said:I will push back on the powder-first advice.
Adding the part of the answer the thread has not reached. The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously. On the positive side: reduced anxiety around food, better self-image, more confidence. On the difficult side: grief for the years lost, identity disruption, relationships built around eating, and the loss of food as a coping mechanism with nothing put in its place. Rarer but real: anhedonia and emotional flatness. Regulators have started asking for validated patient-reported outcomes in this class; the existing data gap is not evidence of absence.
Worth separating that from mood and mental health, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Sigma-Aldrich — Research-Grade Standards
Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.
Shop Reference StandardsOne thing that is still open after Dr.EndoEP’s answer:
How people are hitting a protein target on a genuinely suppressed appetite, because volume is the binding constraint rather than willingness?
Closing the loop on my own question.
Update: two thirds of the target before midday. Same total, same appetite, and I am hitting it most days now.