Dr.KarenChen said:Mostly the deficit, and the useful part of that answer is that it is testable.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
alex_tucson said:The mechanism that matters here is not stomach emptying, it is central.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
Dr.KarenChen said:Mostly the deficit, and the useful part of that answer is that it is testable.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Browse GL BiochemAdding the numbers, since they settle part of this. Worth checking before concluding it is the drug: ferritin, B12, TSH, and total intake for three honest days. Two of those four explain most cases.
Correct me if the detail matters more than I have assumed.