Dr.ObesityLA said:The liver data is among the strongest non-weight findings in the class.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
hans_munich said:Steady state is the thing most people miss.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.
Dr.ObesityLA said:The liver data is among the strongest non-weight findings in the class.
Pushing back on Dr.ObesityLA here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsOne concrete data point for the thread. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.