Alcohol simply stopped appealing, which I did not expect and which has been more socially complicated than the weight loss.
What I am after is whether the change in tolerance is the smaller stomach, the smaller body, or something central, and whether it settles.
Practical detail welcome, however dull — the duller the better.
This one has a reasonably settled answer, so here it is. The liver data is among the strongest non-weight findings in the class. The semaglutide MASH programme reported a large advantage over placebo on MASH resolution, with a substantial minority also achieving fibrosis improvement — and fibrosis is the endpoint that predicts outcomes. Mechanistically it is reduced hepatic lipogenesis, increased fatty-acid oxidation, less hepatic inflammation, and possibly a direct effect on stellate-cell activation.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
JennaRN said:The liver data is among the strongest non-weight findings in the class.
Agreed, and ALT falling is not the same as fibrosis improving. Enzymes are a crude proxy; FIB-4 or elastography is what tells you about the thing that matters.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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Shop Reference StandardsAdding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.