kate.chem said:The useful checklist is about verifiability rather than presentation.
I disagree that testing history is decisive. It tells you what a supplier did when they were being watched. Continuity of behaviour under stress — a late shipment, a failed test, a complaint — is more predictive than any run of good results.
One concrete data point for the thread. The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as well as purity. A report failing any of those is weak evidence regardless of the percentage on it.
Dr.GutHealth said:I disagree that testing history is decisive.
Coming at Dr.GutHealth’s question from a different direction. They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.
Sigma-Aldrich — Research-Grade Standards
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Shop Reference StandardsA narrower follow-up, since the general answer is now clear:
How people are distinguishing a supplier having a bad batch from a supplier on the way out?
Closing the loop on my own question.
Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality changed. I was reading the product and not the behaviour.