TrialNerd_Beth said:The mechanism that matters here is not stomach emptying, it is central.
I read this differently from TrialNerd_Beth, on substance rather than tone. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
The figures, for anyone assembling their own picture. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.
Dr.NateNeph said:The trial means are being read too generously in this thread.
There is a second half to this that has not been said yet. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
I would rather be corrected than agreed with, if it comes to it.
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Browse GL BiochemA narrower follow-up, since the general answer is now clear:
What would you measure differently if you were starting again?
Reporting back.
Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.