From the other side of the consultation, briefly.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 274 | 234 | 224 | 209 |
| A1C (%) | 7.9 | 6.4 | 5.5 | 5.6 |
| hsCRP (mg/L) | 9.0 | 5.0 | 1.5 | 1.0 |
| Triglycerides | 184 | 154 | 134 | 104 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/week, protein 1.4g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
VanRx_Mike said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 274 234 224 209 A1C (%) 7.9 6.4 5.5…
Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.
VanRx_Mike said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 274 234 224 209 A1C (%) 7.9 6.4 5.5…
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
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View ResultsVanRx_Mike said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 274 234 224 209 A1C (%) 7.9 6.4 5.5…
DEXA scan update relevant to lean mass:
Scanned at months 0, 6, and 12. Here are the body comp numbers:
| Baseline | Month 6 | Month 12 | |
|---|---|---|---|
| Total mass | 276 lbs | 226 lbs | 193 lbs |
| Fat mass | 96 lbs | 76 lbs | 43 lbs |
| Lean mass | 149 lbs | 151 lbs | 150 lbs |
| Body fat % | 45% | 31% | 22% |
Lean mass preserved — actually GAINED 1-2 lbs thanks to progressive overload + 1.5g/kg protein. The lean mass discussion needs to include body comp data, not just scale weight.