Dr.GastroMayo said:The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate…
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 272 | 247 | 212 | 207 |
| A1C (%) | 6.7 | 6.2 | 6.1 | 5.4 |
| hsCRP (mg/L) | 7.0 | 5.0 | 1.5 | 0.8 |
| Triglycerides | 232 | 152 | 132 | 92 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/week, protein 1.2g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
One thing that is still open after andrew_nyc’s answer:
Whether resistance training and protein change the ratio or only the absolute amount?
BiostatsBrad said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 272 247 212 207 A1C (%) 6.7 6.2 6.1…
Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Lumbar spine T-score: -0.8 → -0.6 (stable to slightly improved)
Femoral neck T-score: -0.9 → -0.7 (stable)
No significant bone loss despite 50 lbs of weight loss. Key factors: adequate calcium (1200mg/day), vitamin D (5000 IU/day), resistance training 3x/week, and adequate protein. Weight-bearing exercise is critical for maintaining bone density during rapid weight loss.
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Second scan under matched conditions came back with the lean number nearly a kilogram higher than the first, so a chunk of what I panicked about was hydration. Strength numbers were up throughout.
Dr.ObesityLA said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution. Hydration status moves the lean compartment by a kilogram or more between scans, so any comparison of scans done at different times of day or different hydration states is noise.