Dr.RaviCardio said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.
Dr.RaviCardio said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
That reframing is the part I needed. Taking it to my next appointment.
From the other side of the consultation, briefly. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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Browse GL BiochemDr.EM_Chicago said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.
Dr.EM_Chicago said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
There is a second half to this that has not been said yet. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.