traveltech_sara said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Coming at traveltech_sara’s question from a different direction. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
Following on from traveltech_sara — and this may be the naive question:
Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?
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Browse GL Biochemraj_cambridge said:For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
raj_cambridge said:For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.
Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.