roxy_nash said:Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).
Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.
PharmHunterJen said:The mechanism is more central than most summaries suggest.
That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.
roxy_nash said:Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).
Pushing back on roxy_nash here. I would resist the confidence. Half of what this board was certain about two years ago has since been quietly dropped, and nobody went back to correct the threads.
Correct me if the detail matters more than I have assumed.
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Browse GL BiochemThe figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.