julia.endo said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
hans_munich said:The mechanism is more central than most summaries suggest.
That reframing is the part I needed. Adding it to my notes with a link back to this thread.
julia.endo said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.
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