Dr.EndoEP said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Adding the part of the answer the thread has not reached. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.
Ask again with the specifics and you will get a better answer than this one.
Adding the numbers, since they settle part of this. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.
One thing that is still open after Dr.EndoEP’s answer:
How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?
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Shop Reference StandardsSleepDoc_PDX said:One habit that pays for itself: post the method alongside the number.
I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.
Reporting back.
Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.