Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.
So the question, as narrowly as I can put it: whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.
Happy to be told the question itself is wrong.
Short answer first, then the reasoning. The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study. A curve that has not flattened is a real finding, but it also means the true plateau is unknown, and phase 2 populations are small and selected.
I would rather be corrected than agreed with, if it comes to it.
InsuranceTom said:The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.
Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale. Triple agonism means three receptor systems generating adverse events, and the dropout column is the one I would read first when the larger trials report.
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Browse GL Biochemjennifer_SEA said:Trying to work out whether my panel improved or merely rearranged itself, because two of the numbers went the wrong way.
Same pattern here, and in the same order.
From the other side of the consultation, briefly.
Comprehensive lipid panel update relevant to the lipid panel:
| Marker | Baseline | 6 Months | 12 Months | Reference |
|---|---|---|---|---|
| Total Cholesterol | 247 | 202 | 192 | <200 |
| LDL | 152 | 127 | 112 | <100 |
| HDL | 45 | 46 | 59 | >40 |
| Triglycerides | 267 | 182 | 102 | <150 |
| LDL-P | 1487 | 1237 | 887 | <1000 |
The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.