TrialTracker_MD said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
That is the short version; the long version is somebody else's post.
NicoleRaleigh said:The dose-response is real but shallow at the top.
Bookmarking. The distinction being drawn above is the one nobody else makes.
TrialTracker_MD said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsOne concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.
I would rather be corrected than agreed with, if it comes to it.