EndoResFellow said:The version of this that has an answer is narrower than the version being asked.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
JenPlateau said:Steady state is the thing most people miss.
Thank you — that is the clearest version of this I have read, and I have read a lot of them.
EndoResFellow said:The version of this that has an answer is narrower than the version being asked.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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Shop Reference StandardsThe figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.