LindaRN_retired said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
NurseKim_ATL said:Steady state is the thing most people miss.
This answered a question I did not know how to ask. Sending this to two other people who asked me the same thing last week.
LindaRN_retired said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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