Dr.ObesityMed said:Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.
Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.
Adding the clinical framing, because it changes how the question reads.
Sleep changes on sleep apnoea: anyone else sleeping differently? I've been sleeping better since starting week 2.
My theory: the weight loss has improved my sleep apnea (confirmed by recent sleep study — AHI dropped from 29 to 5). Better oxygenation at night = better sleep quality = more energy during the day. It's a virtuous cycle.
Dr.AddMedPHL said:SURMOUNT-1 landed around 20.9% mean weight loss at 15mg over 72 weeks, against roughly 15% for semaglutide 2.4mg in STEP 1.
Month 15 update on sleep apnoea: down 42 lbs from my starting weight of 267 lbs. Here's what's changed beyond the scale:
- No longer pre-diabetic (A1C normalized)
- Off blood pressure medication
- Can tie my shoes without getting winded
- Sleep apnea resolved — returned my CPAP
- Confidence level: through the roof
This medication has genuinely given me my life back. I'm not exaggerating. 🙌
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View ResultsAdding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
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