One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Following on from Dr.NutriCornell — and this may be the naive question:
How much of the oral variability is the SNAC absorption window and how much is dose, because the two get conflated constantly?
Dr.NateNeph said:For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.
Coming at Dr.NateNeph’s question from a different direction. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
That is the short version; the long version is somebody else's post.
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Follow-up: moving the tablet to the moment I wake, before anything else, was the whole fix. The dose never changed.
paige_pharma said:It is worth asking what the claim would look like if it were false.
That is correct as far as it goes, and here is where it stops going. Worth adding that the tablet is taken daily, so a missed dose costs far less than a missed weekly injection. That is a genuine advantage nobody lists.