claudia_zurich said:Steady state is the thing most people miss.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
Dr.SurgeonPGH said:Worth adding that the tablet is taken daily, so a missed dose costs far less than a missed weekly injection.
That reframing is the part I needed. I will report back once I have actually tried it.
claudia_zurich said:Steady state is the thing most people miss.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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View ResultsThe figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Worth separating that from semaglutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.