Dr.EM_Chicago said:Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.
That reframing is the part I needed. Printing the relevant bit and taking it with me.
From the other side of the consultation, briefly.
The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related hospitalizations in GLP-1 agonist users[1].
The mechanism is plausible: GLP-1R is expressed in the mesolimbic reward pathway (VTA, nucleus accumbens). Agonism at these receptors may reduce the reinforcing properties of alcohol, similar to the reduction in "food noise."
RCTs for GLP-1 agonists in AUD are now underway. If positive, this would be a paradigm-shifting repurposing of existing medications.
[1] Wang W, et al. Nat Med. 2024;30:574-584.
PharmacoVig_BOS said:TrialTracker_MD said: ...regarding food noise mechanism of action...
I read this differently from PharmacoVig_BOS, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
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Moderator note: the sourcing question belongs in the vendor section and has been split out. No action needed from anybody.