hyun_seoul said:The pharmacokinetics explain nearly every practical question asked here.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
steve_okc said:True, though the ladder is longer and that is not a neutral detail — six dose steps means six opportunities to stall on the way up, and plenty of…
Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.
hyun_seoul said:The pharmacokinetics explain nearly every practical question asked here.
I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.
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View ResultsAdding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
Correct me if the detail matters more than I have assumed.
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