SleepDoc_PDX said:Relative and absolute effects need reading together.
Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.
BethLabQueen said:The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.
This answered a question I did not know how to ask. I will report back once I have actually tried it.
SleepDoc_PDX said:Relative and absolute effects need reading together.
I read this differently from SleepDoc_PDX, on substance rather than tone. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.
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View ResultsOne concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.