Nov 3, 2024 at 10:30 PM#11
MASHdoc_SA said:Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
Last edited: Nov 4, 2024 at 4:30 AM
6 4jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 3 others
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Nov 4, 2024 at 11:20 AM#12
Dr.NephBHM_UK said:The mechanism is more central than most summaries suggest.
Bookmarking. The distinction being drawn above is the one nobody else makes.
Last edited: Nov 4, 2024 at 1:20 PM
7 5Dr.RheumBOS, greg_boulder, quinn_sf and 4 others
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Nov 5, 2024 at 12:10 AM#13
MASHdoc_SA said:Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…
I read this differently from MASHdoc_SA, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
8 6KevinCompounds, TirzTom, TrialTracker_MD and 5 others
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View ResultsNov 5, 2024 at 1:00 PM#14
The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
9 7andrew_nyc, Dr.EndoEP, GraceAZ_72 and 6 others
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