Dr.ObesityLA said:It helps to ask what evidence would change your mind before you look at any.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
SurmountFan_IN said:Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak.
Genuinely useful, thank you. I had the facts and not the framework.
Dr.ObesityLA said:It helps to ask what evidence would change your mind before you look at any.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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View ResultsThe figures, for anyone assembling their own picture. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.