Dr.SleepRoch said:"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.
Central vs peripheral GLP-1R signaling in food noise: elegant studies using brain-penetrant vs peripherally-restricted GLP-1 agonists show that ~80% of the weight loss effect is centrally mediated[1].
The key brain regions: arcuate nucleus (appetite), area postrema (nausea), NTS (satiety), VTA/NAc (reward). Peripheral effects (gastric emptying, insulin secretion) contribute but are secondary for weight loss.
This has implications for next-gen drugs: optimizing brain penetration and CNS receptor occupancy may be more important than systemic exposure.
[1] Secher A, et al. J Clin Invest. 2014;124(10):4473-4488.
chris_chi24 said:Alcohol relationship change with food noise: I used to drink 2 glasses of wine most nights.
Genuinely useful, thank you. I had the facts and not the framework. Printing the relevant bit and taking it with me.
Dr.SleepRoch said:"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.
Pushing back on Dr.SleepRoch here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
Correct me if the detail matters more than I have assumed.
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Shop Reference StandardsThe figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.