Dr.RaviCardio said:Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…
Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.
Found this through search years later and it is still the best discussion of the question, so adding one thing. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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For the archive: it took about six weeks rather than the two I expected, and the difference between those two numbers was the whole of my problem.
GenomicsKate said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Coming at GenomicsKate’s question from a different direction. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.