Dr.ReproEndo said:The mechanism is more central than most summaries suggest.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
Dr.AddMedPHL said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
This answered a question I did not know how to ask. Taking it to my next appointment.
Dr.ReproEndo said:The mechanism is more central than most summaries suggest.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
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View ResultsThe figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.