SarahChen_PharmD said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
There is a second half to this that has not been said yet. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.
The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
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Browse GL BiochemHPLC_Greg said:If you are going to change something, change one thing and give it long enough to express itself.
Pushing back on HPLC_Greg here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.
HPLC_Greg said:If you are going to change something, change one thing and give it long enough to express itself.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.