KevinCompounds said:The mechanism and the magnitude are separate questions.
Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.
Ask again with the specifics and you will get a better answer than this one.
PharmD_Rodriguez said:Agreed on the target, with the caveat that reference weight and current weight are different numbers.
Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.
KevinCompounds said:The mechanism and the magnitude are separate questions.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
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Browse GL BiochemOne concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
I would rather be corrected than agreed with, if it comes to it.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.